Leonardo da Vinci’s genius is often mythologized as otherworldly or supernatural. In what ways does Isaacson’s biography demystify Leonardo’s genius, and what argument does the book make about the nature of human creativity? Discuss how the author reframes genius as a product of curiosity, observation, and interdisciplinary thinking rather than innate brilliance alone.

Consider Isaacson’s use of Leonardo’s notebooks as a narrative device. How do the notebooks shape the structure, style, and thematic thrust of the biography? Analyze how the inclusion of seemingly trivial entries—such as “describe the tongue of the woodpecker”—reinforces the book’s core message about the value of wonder-driven inquiry.

Compare and contrast Leonardo’s scientific studies with his artistic pursuits. How does Isaacson argue that Leonardo’s fusion of art and science exemplifies Renaissance humanism? In what ways does the book challenge modern distinctions between the fields of science, technology, engineering, and math (STEM) and the arts?